Revolutionizing Cancer Treatment with Targeted Protein Degradation In the evolving landscape of cancer therapeutics, researchers have achieved a significant milestone…
Breaking the Size Barrier in Cryo-EM Structural Biology Electron cryo-microscopy has revolutionized structural biology, enabling researchers to visualize biological macromolecules…
Researchers have uncovered a novel disease mechanism in Teebi hypertelorism syndrome involving disruption of protein translation initiation. The study reveals how an intragenic deletion activates alternative start sites, producing truncated proteins that contribute to the disorder’s characteristic features.
Scientists have identified a previously unknown disease mechanism in Teebi hypertelorism syndrome 1 (TBHS1), according to a recent case study published in npj Genomic Medicine. The research reveals how an intragenic deletion disrupts normal protein translation initiation, leading to the production of abnormal protein isoforms that contribute to the disorder’s characteristic craniofacial features.
Researchers have developed ANGEL, a breakthrough nanobody-guided approach for efficient fluorescent labeling of endogenous proteins. This innovative technique enables real-time visualization of protein dynamics under native regulatory conditions.
In a significant advancement for molecular biology and cellular imaging, researchers have developed a nanobody-guided approach that enables efficient fluorescent labeling of endogenous proteins. This breakthrough technique, termed ALFA Nanobody-guided Endogenous Labeling (ANGEL), addresses long-standing challenges in visualizing and screening small peptide knockins without fluorescence interference.
