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Scientists Engineer Living Computers with Three-Input Genetic Circuits

Researchers have developed a complete set of three-input biological computing circuits capable of performing all 256 possible Boolean logic operations. The breakthrough represents a significant scaling of cellular computing capabilities, moving synthetic biology closer to practical applications in biosensing and medical diagnostics.

In what sources describe as a major leap forward for biological computing, researchers have successfully engineered living cells capable of processing three distinct inputs to perform complex decision-making operations. According to reports published in Nature Communications, the team has expanded their T-Pro biocomputing platform to handle 256 different Boolean logic operations—a sixteen-fold increase over previous two-input systems.

Engineering Cellular Wetware

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Malaria Parasite’s Essential Trafficking Protein Reveals New Drug Target Potential

Researchers have characterized a previously unknown essential protein in malaria parasites that appears critical for cellular transport mechanisms. The discovery of PfPX2’s binding capabilities and localization patterns opens new avenues for understanding parasite biology and potential therapeutic interventions.

Breakthrough in Understanding Malaria Parasite Biology

Scientists have identified a previously uncharacterized protein essential for the survival of Plasmodium falciparum, the deadliest malaria parasite, according to recent research published in Scientific Reports. The protein, named PfPX2, appears crucial for the parasite’s in vitro asexual growth and may play a key role in cellular transport mechanisms between critical organelles.