Ligand (biochemistry)

DNA Injection Technique Produces Long-Lasting COVID Antibodies in Human Trial

A novel DNA-based approach has demonstrated the ability to produce stable, broadly neutralizing antibodies against COVID-19 for at least 72 weeks in human volunteers. The technique combines plasmid DNA injections with electrical pulses to turn muscle cells into antibody factories. While promising, the method faces practical deployment challenges and potential public acceptance hurdles.

A New Frontier in Antibody Production

Researchers have reportedly achieved what many in biotech have been chasing for years: getting human bodies to manufacture their own protective antibodies against viruses for extended periods. According to newly published clinical trial results in Nature Medicine, a technique combining DNA injections with electrical pulses successfully produced stable COVID-19 antibodies in volunteers for at least 72 weeks—and potentially much longer.

by Jessica Moore P.E.October 24, 2025

Assistive Technology Earth Sciences

Nanobody-Guided ANGEL Technique Enables Efficient Endogenous Protein Fluorescent Labeling

Researchers have developed ANGEL, a breakthrough nanobody-guided approach for efficient fluorescent labeling of endogenous proteins. This innovative technique enables real-time visualization of protein dynamics under native regulatory conditions.

In a significant advancement for molecular biology and cellular imaging, researchers have developed a nanobody-guided approach that enables efficient fluorescent labeling of endogenous proteins. This breakthrough technique, termed ALFA Nanobody-guided Endogenous Labeling (ANGEL), addresses long-standing challenges in visualizing and screening small peptide knockins without fluorescence interference.